Big Pharma prefers medicines with a defined mode of action (MoA). It eases regulatory approval, reimbursement by public insurance, marketing, and communication with the physicians. Side effects are accepted as collateral damages. Studies for the approval of new topical eye drops frequently compare the new drug with its vehicle (i.e. the drug formulation without the … Continue reading Homeostasis of the Ocular Surface
Antibiotic resistance among ocular microorganisms
Ideally, in any ocular infection, identification of the causative microorganisms and determination of their antibiotic resistance should precede initiation of antibiotic therapy. However, in practice bacterial cultures are only performed for vision-threatening ocular infections, whereas, cultures are rarely performed for routine infections. Penny Asbell and colleagues recently published the antibiotics resistance of 6091 isolates received … Continue reading Antibiotic resistance among ocular microorganisms
Hyaluronan supports wound healing in diabetes
The application of high molecular weight hyaluronan (hyaluronic acid) eye drops is likely to be indicated before and after any ocular surgery in diabetic patients. In 2011 Galeano et al. reported that the skin of diabetic mice contains one third less hyaluronan than that of non-diabetic mice of the same race (https://www.sciencedirect.com/science/article/pii/S0925443911000676?via%3Dihub). It was known … Continue reading Hyaluronan supports wound healing in diabetes
Dr. Mueller-Lierheim 